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West China Institutes for Women and Children's Health

The aims of the Institutes'are:
To be the best platform for teaching and research in the field of maternal and child health in the country
To be a training base for innovative talentsin the field of maternal and child health in West China and the country as well
To be a national and international research centre involving talent exchange and cooperation in the field of maternal and child health
To be a platform for newly developed cross-disciplinary research and a front of scientific innovation in the field of maternal and child health
To provide conditions to accelerate research into practice

Supported by the West China Second University Hospital, Sichuan University, the Institutes are committed to innovation and cross disciplinary collaboration, and run with a mechanism of "opening, mobility, cooperation and competition".

Established in 2008, the institutes now have The Development and Stem Cell Institute,The Joint Research Center of West China Second University Hospital of Sichuan University and Faculty of Medicine, the University of Hong Kong, Lab on Early Development Injury and Repair, Child Neuroscience Laboratory, Lab of Development and Disease, Laboratory of molecular translational medicine/Lab of Immunogenetics, Laboratory of Biotherapy for Gynecological Tumor,Gynecological Oncology Laboratory,Biomedical Ultrasonics Laboratory, Laboratory of Genetic Disease/Perinatal Medicine,The Laboratory of Genetics,Lab of Cell and Gene Therapy,Laboratory on Molecular Epidemiology of Birth Defects, Laboratory of Pediatric Hematology/Oncology, The Pulmonary Vascular Remodeling Research Unit, and The Open Laboratory which provides analytical, consulting and training services to postgraduates and faculty of this hospital. And The National Drug Clinical Trial Institute is also established under The Institutes.

The Organizational Structure of the Institutes

The Institutes are made up of the scholarship committee, the professor committee, the appraisal committee, and the audit committee, which are responsible for the research areas, performance appraisal, supervision and financial audit respectively to ensure the sustainable and successful development of the Institutes.

The Institutes cover an area of over 10000 square meters, with 850 square meters at each floor. They have spacious laboratories and are equipped with state-of-art research apparatus worth over 30 million RMB yuan (over 4.7 million dollars), including flow cytometry, HPLC-MS and confocal microscope and so on, which are shared by the labs.

Management of West China Institutes for Women and Children’s Health

The vision of the Institutes is to be a centre of excellence in research in the field of child and maternal health both nationally and internationally, integrating basic research and clinical practice.

Opening up and mobility of Researchers

We keep pace with the advanced technology by opening up and strengthening the exchange and cooperation with the national and international institutions.

Our labs are open to relative research institutions in the field of maternal and child health at home and abroad, and provide a research platform linking scientific research and clinical practice. Meanwhile the positions in the labs are open for excellent researchers worldwide.

We are actively involved in holding diversified academic activities, taking part in high-level academic conferences, and inviting experts and scholars for academic exchanges. Also renowned scientists are invited to do research in the Institutes so as to improve its core competiveness in disciplinary development, and excellent researchers will be introduced nationally and internationally, raising the international reputation of the Institutes and Sichuan University.

Based upon performance appraisal, mobility of researchers is essential for working out the potential of the researchers. Meanwhile, elimination mechanism for researchers is introduced so that unqualified ones will be eliminated and excellent researchers can have more research resources. Thus more talents can be attracted and their enthusiasm be aroused.

Cooperation and competition

Cooperation is the basis of competition, and competition is the motivation, which can lead to a redistribution of research resources, and ensure a qualified team of researchers. We encourage competition among cooperation, and this mechanism guarantee the competitive edge  and sustainable movement of the Institutes.

Introduction of PIs and Co-PIs of the Institutes

Dr.LI Huashun, MD & PhD, is the principal investigator and the director of West China Developmental & Stem Cell Biology Institute (DSI) and the professor of Sichuan University. He received his PhD from Washington University School of Medicine in St. Louis, Missouri, USA in 1999. His primary research interest is Developmental & Stem Cell Biology.Since joining DSI 2007, he has been responsible for two key projects from Ministry of Science and Technology of China, and two supported by National Natural Science Foundation of China. And he has published 9 papers in Cell, Neuron, Gene & Development, Nature Neuroscience and Development, which are cited for over 960 times.

Dr.JIANG Changan, Ph.D., is a principal investigator at West China Developmental & Stem Cell Biology Institute (DSI), Sichuan University. He received his Ph.D. from University of Utah, USA in 1999. Since joining DSI in 2007, his research focuses on understanding the molecular mechanisms and developing novel therapies for Parkinson’s Diseases (PD), and is supported by the 2008 Program for New Century Excellent Talents in University of Ministry of Education of China. He has got breakthroughs in long QT syndrome, apoptosis and Parkinson’s Diseases. He is currently responsible for two key projects from Ministry of Science and Technology of China, two supported by National Natural Science Foundation of China, and one supported by Program for New Century Excellent Talents in University of Ministry of Education of China. And he has published 9 papers including 5 in Cell, Neuron, Gene & Development, Nature Neuroscience and Development, which are cited by SCI for over 1760 times. And his discoveries have been reported by worldwide news media like CNN, and New York Times, also by Howard Hughes Medical Institution and Nature.

Dr.LU Qing,associate professor of UT Southwestern Medical Center and professor of West China Second University Hospital,Sichuan University, is a principal investigator at West China Developmental & Stem Cell Biology Institute (DSI), Sichuan University. His primary research interest is transcriptional regulation of neural stem cell differentiation/gliogenesis. He won many awards including the Best 'Mature' Scientific Study Award from Dana-Farber Cancer Institute(2002), Fellowship Award from the Charles A. King Trust and the Medical Foundation (2001) and National Research Service Award Fellow from NIH (1998). And over 10 of his research papers were published in key journal like Cell, Nature Neuroscience, Neuron, PNAS, Development, and cited for over 900 times.

Dr.LI Hedong, Professor, obtained a Bachelor of Arts and a Master's Degree in Biology from Nankai University, Tianjin, P.R.China and a doctorate in molecular neuroscience from Wayne State University, Michigan in 1999. He was trained as postdoc in Dr.Martin Grumet’s lab at Rutgers University and became research assistant professor in 2005 at M.W.Keck Center for Collaborative Neuroscience at Rutgers University.In 2009, Dr.Li was invited to join the West China Developmental & Stem Cell Biology Institute (DSI), West China Second University Hospital,Sichuan University as a principal investigator.And Dr.Li has more than 10 years of experience on neural stem cell research and has generated multiple neural stem cell lines that have been shown to have both neuroprotective and regenerative effects in a rat contusion spinal cord injury model.His research has been published in J Cell Biol, Dev Biol, GLIA, Exp Neurol, Dev Neurobiol.

Dr.Wan Huajing, Ph.D, is a full-time associate professor and principal investigator of West China Development and Stem Cell Institute,West China Second University Hospital, Sichuan University.

Dr. Wan got a bachelor of medicine from the former West China University of Medical Sciences, P.R.China, and received her Ph.D. from the University of Cincinnati, U.S.A, and completed the research fellowship program at Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Medical Center.

Dr.Wan led and completed several seminar studies of importance in the field of lung development and diseases. Her papers are published in the journals of Development, PNAS, J of Immuno, and JBC etc., demonstrating important roles of the transcription factors(FOXA1, FOXA2, CEBPa, SPDEF, KLF5) in the development of lung and development of inflammation, goblet cell hyperplasia, emphysema, and in the pathogenesis of newborn respiratory distress syndrome, BPD and asthma , leading causes of morbidity and mortality in children. And her research was supported by the post-doctoral fellowship program of American Lung Association(RT-82653-N), Young Scientist Fund of China(30700339), New Century Excellent Talents Foundation of China(NCET-09-0572) and key clinical disciplinary project Of the Ministry of Health of China. Dr. Wan is also the key member of the innovation team of the Ministry of Education of China.

Prof.LIU Cong,principal investigator of Developmental and Stem Cell Institute, West China Second University hospital, Sichuan University. He obtained his PhD from Sussex University and completed the postdoctoral training with Prof Tony Carr and Penny Jeggo in the MRC/Genome Damage and Stability Centre. Once being a genetist, he worked on fission yeast to investigate the molecular mechanism of checkpoint activation and cell cycle progression. Later he joined the European Framework Project to establish mouse models defective in DNA structural metabolism. By using various model systems (i.e.transgenic mice and yeast) and clinical materials, his lab of genome stability in Sichuan University is carrying out the work to study the maintenance of genomic integrity and relevant human diseases resulting from disturbing of this signaling network. Their work has shed lights on the pivotal roles of DNA repair in tumorigenesis, neural development and viral infection. His research has been supported by National Natural Science Foundation of China, New Century Excellent Talents Foundation of China and other ministerial and provincial research foundation. And his research papers were published in key journal like Genes & Dev,EMBO J,J.Neurosciences and Nature, and were cited for over 480 times.

Dr.MAO Meng, professor of pediatrics in Sichuan University, doctoral advisor. She is a State Council Expert for Special Allowance and was awarded the outstanding young & middle–aged expert by Ministry of Health of China. Professor Mao Meng is the director of the Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, and the director of the Key Laboratory of Development and Obstetric & Gynecologic and Pediatric Diseases of Sichuan Province. Professor Mao Meng is also in charge of the platform of "Genetic Resources of Chinese Population (GRCP)".  She has led over 10 key projects in the past five years, including Platform Construction Projects of Chinese Education Ministry for Sciences and Technology, National Program on Key Basic Research Project (973 Program), projects supported by National Natural Science Foundation of China, and International and Overseas Cooperation Projects. Professor Mao Meng has published over 150 research papers and authored six medical books as chief editor or associated chief editor. In 2007, the teaching textbook of the 11th Five-Year Plan Pediatrics is awarded as a fine work by Ministry of Education of China. Professor Mao Meng has won the Sichuan Provincial Scientific and Technological Progress Awards (one first-prize and one third-prize),and a Second-prize for Science and Technology Progress Award of the Ministry of Education. She is a vice-chair of the Society of Pediatrics of Chinese Medical Association, chair of the Committee of Child Health Care of Chinese Pediatric Association, chair of both the Sichuan Province Pediatric Association and the Chengdu City Pediatric Association. She also is a member of the Humanitarian committee of the International Academy of Pediatrics.Professor Mao Meng is an evaluation expert of the 11th Five-Year Plan and International and Overseas Cooperation Projects, National Natural Science Foundation of China, and Science and Technology Award of Ministry of Education. She is also a chief editor of the textbook of the 11th Five-Year Plan Pediatrics, chief editor of the appointed textbook of ministry of health Children's Healthcare Science, associated chief editor of textbook of Pediatrics for eight-year-program medical students.Professor Mao Meng is also the chief editor of the Chinese Journal of Obstetrics & Gynecology and Pediatrics (Electronic Edition).

Prof.MU Dezhi graduated from the West China University of Medical Sciences as an M.D.in 1996. From 1996 to 1998, he did post-doctoral programs in Beijing Medical University, and from 1998 to 2004 he was a post doctoral fellow, assistant researcher,and associate adjunct professor in the University of California, San Francisco. In 2004,Dr.Mu was appointed professor by Sichuan University (SCU) and director of the Pediatric Department of West China Second University Hospital, SCU. In 2009,he became the leader of the Innovative Team of The Cheung Kong Scholars Programme of the Ministry of Education. In 2010, Dr. Mu was appointed the president of West China Second University Hospital, SCU. In 2012, he became the Chair of the West China Medical Center of Children.

With over two decades' clinical practice, research, and teaching in pediatrics, Dr. Mu is highly experienced in diagnosing and treating diseases of children, especially neonatals. His research focuses on mechanism and early interventions of hypoxia-ischemic encephalopathy.

Dr. Mu is principal investigator of many research programs, including one from the National Science Fund for Distinguished Young Scholars, four from the National Natural Science Foundation of China, one from the American Heart Association, one from the Innovative Team of The Cheung Kong Scholars Foundation of the Ministry of Education, one from the Key Doctoral Program of the Ministry of Education, six from other Ministries and the Province. Dr. Mu has published more than 200 journal articles which are cited for over 600 times by Nature and SCI-cited journals. He was also an editor-in-chief and principal translator of two pediatric books. Dr. Mu has won two Second Prizes of the Ministry of Education for Science and Technology Progress, one Third Prize of Sichuan Province for Science and Technology Progress, one First Prize of Sichuan Province for Science and Technology Progress in Medicine. He obtained a national invention patent authorization.Up to now, Dr.Mu has tutored thirty candidates for master's and doctor's degree.

Dr. Mu is deputy director of Society of Neonatology, Chinese Medical Doctor Association; committeeman of the Society of Pediatrics, Chinese Medical Association (CMA);deputy director of the Neonatology Subspecialty, Pediatric Society, CMA;deputy director of the Pediatric Society, Sichuan Medical Association; director of Neonatology Subspecialty, Sichuan Medical Association.Dr. Mu is deputy editor-in-chief of the Chinese Journal of Neonatology and Journal of Clinical Pediatrics,editorial board member of World Journal of Pediatrics, Chinese Journal of Pediatrics,Chinese Journal of Contemporary Pediatrics,and Journal of Applied Clinical Pediatrics.

ZHU Jun, doctoral advisor, the director of National Office for Maternal and Children Health Surveillance/National Center for Birth Defects Monitoring of China, the principal investigator of Laboratory of Molecular Epidemiology of Birth Defects,the Chinese project leader who is responsible for international birth defects information exchange,a member of national prenatal diagnosis technology expert team and national neonatal screening technology expert team. Her research interests include monitoring system of birth defects, epidemiology of birth defects, and etiology of birth defects. She has conducted the basic etiologic research of major birth defects, and obtained research grants from the "973" projects, established bio samples bank of many types,including pedigrees of major birth defects,Case-parent Triads and sporadic cases. She has published over 100 papers,including over 20 in SCI journals,authored 3 and coauthored 5 medical books. She also won the first-prize of Sichuan Provincial Scientific and Technological Progress Award, the award for her contribution in the progress of public health and preventative medicine by Chinese Preventive Medicine Association, excellent paper by Chinese Medical Association.

Prof.WANG He,professor of Ob/Gyn,doctoral advisor,director of Prenatal Diagnosis Center of Sichuan Province.He was the visiting scholar and senior scholar in Erasmus University and Leiden University, The Netherlands, University of Michigan and Duke University, USA. His primary research interests include prenatal screening and prenatal diagnosis of birth defects. He has conducted four research programs supported by National Natural Science Foundation of China. He was also involved in the major research programs supported by NNSFC, National Tenth-five and Eleventh-five key projects. He has published over 10 papers in key journals like Nature Biotechnology,Cancer Research, PNAS and Clinical Cancer Research.

Prof.MA Zhigui, professor of West China Second University Hospital, Sichuan University, doctoral advisor, Academic Leader of Sichuan Province, member of American Society of Hematology (ASH), winner of  the Program for New Century Excellent Talents in University of Ministry of Education of China, principal investigator of Laboratory of Pediatric Hematology/Oncology in the institutes. He was a postdoctoral fellow and staff scientist at the Department of Pathology of St. Jude Children's Research Hospital during 1998 -2005, and won the ASH Merit Award in 1999, and he was the first to clone two novel genes, RBM15 and MKL1 relating acute megakaryoblastic leukemia in 2001. His research currently focuses on the oncogenic role of ALK and the molecular mechanisms of glucocorticoid resistance in lymphoid malignancies. He currently has two projects supported by the National Natural Science Foundation of China, and published over 20 papers in the leading international journals including Leukemia, Blood and Nature Genetics.

Dr.Hsiao Chang CHAN, Ph.D., Director of Sichuan University - Chinese University of Hong Kong Joint Laboratory for Reproductive Medicine, also Li Ka Shing Professor of Physiology of the Chinese University of Hong Kong. She has established the first Epithelial Cell Biology Research Center in China in 1999, and has since then committed to the epithelial cell biology and reproductive biology research and promoted the development of related fields in China, her work has published in a series of leading international journals including Science, Nature Cell Biology, Lancet, PNAS with nearly 200 articles, and has been cited near 3000 times. She also served editorial boards in the "Physiology", "Journal of Physiological Sciences",Cell Biology International "," Chinese Science "," Reproductive and Developmental Biology "," Reproduction and contraception" and other international scientific journals; and served as a reviewer for grant applications to the World Health Organization (WHO), the U.S. national Science Foundation, the British Welcome Trust etc. She has led or participated in "973", the National Natural Science Foundation and the Hong Kong"RGC" over 20 major research projects, thus enjoyed a high academic reputation in the epithelial cell biology and related fields.Created in 2009, the Sichuan University-Chinese University of Hong Kong Joint Laboratory of Reproductive Medicine located in West China Second University Hospital of Sichuan University, and served as an important platform to promote cooperation between the Mainland China and Hong Kong.

Prof.ZHAO Xia, MD, professor, doctoral advisor, director of Department of Obstetrics and Gynecology, Ex-deputy Dean of West China Second Hospital, Sichuan University. Professor Zhao Xia received her undergraduate degree from West China University of Medical Sciences, Chengdu, China in 1983 and her M.D. in Gynecology from the same university. She undertook overseas study in Kyoto University, Japan and the University of Arkansas, USA and was elected as professor and doctoral advisor of Gynecology in West China Second Hospital, Sichuan University in 2003. Currently, she holds the position of Academic Leader of Sichuan Province, Academic Leader of Department of Public Health of Sichuan Province, member of the Standing Committee of Gynecological Oncology Sub-Committee of Chinese Medical Association, Vice Chair of Endoscopy Committee of the Commission for Examination and Assessment of Professional Technologies of Ministry of Health, Vice Chair of National Endoscopic and Minimally Invasive Professional and Technical Evaluation Committee, member of Nano-biology Professional Committee of Chinese Association of Biotechnology, Director of Gynecological Training Base of Endoscopic Diagnosis and Treatment Technology, and Vice Director of West China Training Center of Gynecological Oncology Association of Chinese Medical Association. Professor Zhao is known and experienced in the treatment of gynecological malignancies as well as her in-depth research in the field of nanotechnology and gene therapy. In addition, she is dedicated to explore novel drugs to improve the therapeutic efficacy of cancers as well as investigate cancer chemoresistance and slow-release formulation for abdominal chemotherapy. And she obtained over 10 grants including one from National Key Technologies R&D Program, 2 from National 973 Program of China, 3 from National Basic Research Program of China, 2 from National Natural Science Foundation of China, and 3 from Provincial Foundation of Sichuan, with a total fund of over 20 million RMB. In addition, Professor Zhao obtained over 10 national patents. Her project “The Research Osteoporosis and Coronary Heart Disease in Menopausal Women” won the Second Prize of Sichuan Science and Technology Progress Award and the project "Comparative Study of the Ultra-structures of Human Cancer and Embryo" won the Third Prize of Chengdu Science and Technology Progress Award. In recent years, Professor Zhao has published 66 original articles in internationally peer reviewed journals including Mol Cell Proteomics, Blood, Cancer Res, Clin Cancer Res, J Immunol, JBC, Mol Cancer Ther, Molecular Cancer Res, Hum Gene Ther, Growth Factors, J Mater Sci. Mater Med.

Prof.YU Tinghe, M.D., Ph.D., is a Professor and Principal Investigator in the Institutes for Women and Children's Health, the Second Hospital of Sichuan University, and a Chair Professor of Bayu Scholars (Chongqing Municipality, China). His research focuses on gynecological cancers and biomedical ultrasonics. He is a winner of New Century Excellent Talents in University (NCET) from the State Ministry of Education. He has won 6 grants from Natural Science Foundation of China and the State Ministry of Education, and published more than 30 papers in international peer-reviewed journals. He is also an external reviewer of Eur Radiol, Cancer Lett and Ultrason Sonochem etc.

Prof.ZHANG Lin, doctoral advisor, outstanding expert of Ministry of Health, winner of Trans-Century Training Program Foundation for Talents from the Ministry of Education of China, academic leader of Sichuan Province. He has been engaged in researches in the field of molecular genetics and cellular biology. His research was supported by the funds of National Program on Key Basic Research Project of China (973 Program), the National High Technology Research and Development Program of China (863 Program), the National natural Science Foundation of China, the Key Project of Chinese Ministry of Education, and the China Medical Board of New York Inc. (CMB). He has published over 100 original research articles, more than 60 papers in international journals. And he edited one appointed medical textbook of national Eleventh-five program, and co-edited 4 books.

Prof.LIN Yong, Ph.D., doctoral advisor, worked at the National Cancer Institute (NCI) of National Institutes of Health (NIH) in the United States as a postdoctoral fellow from 1998 to 2004. In the past 10 years, he has being engaged in researches in cellular signal transduction and made substantial accomplishments. His main research interest is inflammation-associated carcinogenesis, chemoprevention and chemotherapy. He has published more than 60 papers in international journals including Nature Immunology, Immunity, Molecular Cell, Genes & Development, Molecular Cellular Biology, Journal of Biological Chemistry, PNAS and Cancer Research. His recent research is focused on the roles and mechanisms of cell signaling that regulates cell survival and death in cancer development and chemoresistance, which could be implicated in cancer prevention and therapy.

Prof.HU Huaizhong, PhD. His research focuses on immunology, molecular biology, hematology, toxicology. He has engaged in research in the Netherlands, Singapore and the USA, and trained 4 doctoral candidates in the National University of Singapore. And he has won grants from NIH, Leukemia Research Foundation, and Ministry of Health, Singapore, with a total fund of about one million US dollars. He has published over 50 papers in international journals, and obtained 4 patents in the USA and Australia. He is also a peer reviewer for leading international journals including Blood, Journal of Immunology, American Journal of Transplantation, Transplantation, British Journal of Haematology, Experimental Hematology.